What is A.L.L. ~
Acute Lymphoblastic Leukemia

Acute lymphocytic leukemia (ALL) is a type of cancer of the blood and bone marrow ~ the spongy tissue inside bones where blood cells are made.


The word "acute" in acute lymphocytic leukemia comes from the fact that the disease progresses rapidly and creates immature blood cells, rather than mature ones. The word "lymphocytic" in acute lymphocytic leukemia refers to the white blood cells called lymphocytes, which ALL affects. Acute lymphocytic leukemia is also known as acute lymphoblastic leukemia.


OUR MISSION:

The mission of iAMagainstALL is to eradicate Leukemia as a life-threatening disease by advancing research, education, screening, and treatment.



Enriching the lives of those battling, surviving and defeating A.L.L., acute lymphoblastic leukemia through grants, and/or scholarships and providing emergency monetary access to funds to assist in travel, living expenses and current familiy needs during trying times.


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What is Leukemia?

Answer: Leukemia is cancer of the body's blood-forming tissues, including the bone marrow and the lymphatic system usually involveing the white blood cells, the infection fighters. Our blood cells generally grow and divide in an orderly way, as our body needs them... However in people with leukemia, the bone marrow produces an excessive amount of abnormal white blood cells, which don't function properly.

read more from the Mayo Clinic


What is Acute Lymphoblastic Leukemia?

Answer: Adult acute lymphoblastic leukemia (ALL; also called acute lymphocytic leukemia) is a cancer of the blood and bone marrow causing our bodies to make too many lymphocytes (a type of white blood cell).

ALL is an acute form of leukemia that affects the lymphoid stem cells that produce immature white blood cells (lymphoblasts). The diseases lymphoblasts are poor infection fighters, but they divide rapidly and crowd out healthy cells in the bone marrow.

In ALL, too many stem cells become lymphoblasts, B lymphocytes, or T lymphocytes. These cells are also called leukemia cells. These leukemia cells are not able to fight infection very well. Also, as the number of leukemia cells increases in the blood and bone marrow, there is less room for healthy white blood cells, red blood cells, and platelets. This may cause infection, anemia, and easy bleeding. The cancer can also spread to the central nervous system (brain and spinal cord), lymph nodes, spleen, liver, testicles, and other organs.

read more from The Leukemia & Lymphoma Society


What causes Acute Lymphoblastic Leukemia?

Answer: Acute Lymphoblastic leukemia occurs when a bone marrow cell develops changes (mutations) in its genetic material or DNA. A cell's DNA contains the instructions that tell a cell what to do. Normally, the DNA tells the cell to grow at a set rate and to die at a set time. In acute lymphocytic leukemia, the mutations tell the bone marrow cell to continue growing and dividing.

When this happens, blood cell production becomes out of control. The bone marrow produces immature cells that develop into leukemic white blood cells called lymphoblasts. These abnormal cells are unable to function properly, and they can build up and crowd out healthy cells.

It's not clear what causes the DNA mutations that can lead to acute Lymphoblastic leukemia.

read more from the Mayo Clinic


Symptoms of Acute Lymphoblastic Leukemia?

Answer:

  • small red or purple spots on the skin, nose
  • Bleeding from the gums
  • Bone pain
  • Fever
  • Frequent infections
  • Frequent or severe nosebleeds
  • Lumps caused by swollen lymph nodes in and around the neck, armpits, abdomen or groin
  • Pale skin
  • Shortness of breath
  • Weakness, fatigue or a general decrease in energy

read more from American Cancer Society


How is Acute Lymphoblastic Leukemia Diagnosed?

Answer: Tests and procedures used to diagnose acute lymphocytic leukemia include:

  • Blood tests. Blood tests may reveal too many or too few white blood cells, not enough red blood cells, and not enough platelets. A blood test may also show the presence of blast cells - immature cells normally found in the bone marrow.
  • Bone marrow test. During bone marrow aspiration and biopsy, a needle is used to remove a sample of bone marrow from the hipbone or breastbone. The sample is sent to a lab for testing to look for leukemia cells.

    Doctors in the lab will classify blood cells into specific types based on their size, shape, and other genetic or molecular features. They also look for certain changes in the cancer cells and determine whether the leukemia cells began from B lymphocytes or T lymphocytes. This information helps your doctor develop a treatment plan.
  • Imaging tests. Imaging tests such as an X-ray, a computerized tomography (CT) scan or an ultrasound scan may help determine whether cancer has spread to the brain and spinal cord or other parts of the body.
  • Spinal fluid test. A lumbar puncture test, also called a spinal tap, may be used to collect a sample of spinal fluid — the fluid that surrounds the brain and spinal cord. The sample is tested to see whether cancer cells have spread to the spinal fluid.

read more from the Mayo Clinic


Treatments for Acute Lymphoblastic Leukemia.

Answer: In general, treatment for acute lymphocytic leukemia falls into separate phases:

  • Induction therapy. The purpose of the first phase of treatment is to kill most of the leukemia cells in the blood and bone marrow and to restore normal blood cell production.
  • Consolidation therapy. Also called post-remission therapy, this phase of treatment is aimed at destroying any remaining leukemia in the body.
  • Maintenance therapy. The third phase of treatment prevents leukemia cells from regrowing. The treatments used in this stage are usually given at much lower doses over a long period of time, often years.
  • Preventive treatment to the spinal cord. During each phase of therapy, people with acute lymphocytic leukemia may receive additional treatment to kill leukemia cells located in the central nervous system. In this type of treatment, chemotherapy drugs are often injected directly into the fluid that covers the spinal cord.

Depending on your situation, the phases of treatment for acute lymphocytic leukemia can span two to three years.

  • Chemotherapy. Chemotherapy, which uses drugs to kill cancer cells, is typically used as an induction therapy for children and adults with acute lymphocytic leukemia. Chemotherapy drugs can also be used in the consolidation and maintenance phases.
  • Targeted therapy. Targeted drug treatments focus on specific abnormalities present within cancer cells. By blocking these abnormalities, targeted drug treatments can cause cancer cells to die. Your leukemia cells will be tested to see if targeted therapy may be helpful for you. Targeted therapy can be used alone or in combination with chemotherapy for induction therapy, consolidation therapy or maintenance therapy.
  • Radiation therapy. Radiation therapy uses high-powered beams, such as X-rays or protons, to kill cancer cells. If the cancer cells have spread to the central nervous system, your doctor may recommend radiation therapy.
  • Bone marrow transplant. A bone marrow transplant, also known as a stem cell transplant, may be used as consolidation therapy or for treating relapse if it occurs. This procedure allows someone with leukemia to reestablish healthy bone marrow by replacing leukemic bone marrow with leukemia-free marrow from a healthy person.

    A bone marrow transplant begins with high doses of chemotherapy or radiation to destroy any leukemia-producing bone marrow. The marrow is then replaced by bone marrow from a compatible donor (allogeneic transplant).
  • Engineering immune cells to fight leukemia. A specialized treatment called chimeric antigen receptor (CAR)-T cell therapy takes your body's germ-fighting T cells, engineers them to fight cancer and infuses them back into your body.

    CAR-T cell therapy might be an option for children and young adults. It might be used for consolidation therapy or for treating relapse.
  • Clinical trials. Clinical trials are experiments to test new cancer treatments and new ways of using existing treatments. While clinical trials give you or your child a chance to try the latest cancer treatment, the benefits and risks of the treatment may be uncertain. Discuss the benefits and risks of clinical trials with your doctor.

read more from the Mayo Clinic


Our Story

On June 19, 2014, our family was turned upside down and inside-out when our mom was diagonsed with Acute Lymphoblastic Leukemia. On March 14, 2017, our world was changed forever with the passing of our mom due to a failure to execute within her protocol.

Ami Paige Whitlow-Brown

Mother, Wife, Sister, Daughter, Teacher and a follower of Christ.


ourFAMILY

Mom & Dad
Whit, Chandler & Beckett


myMOM

Ami & Whit

Ami Paige Whitlow-Brown

Many might say the loss of a parent is the single most tragic moment in a child's life and mine was no different.
My world came crashing down on March 14, 2017, at 11:17 a.m., when the execution of my mother's death sentence became my reality. I have spent years trying to articulate how to convey my feelings onto paper into something that would relieve my pain and anger after losing my mother, to no avail.

Before my mom's diagnosis, I was a multi-sport kid in baseball, soccer, and football. My dad was my coach, but my mom was my everything. She cheered me on through every activity I ever joined. My siblings and I considered her our guardian, advocate, and often healer - through her smile. She was a marathon runner who loved life, family, and teaching. In letters written to her by former students, various words defined her character and personality. Words like dedicated, passionate, grateful, compassionate, strong, supportive, and one having a great deal of patience. Everything that I aspire to replicate. She was the rock that held the foundation of our family together, and yet we simply called her mom.

On June 19, 2014, two and half years before my mom's death, my family was hit with a gut punch when she was diagnosed with Acute Lymphoblastic Leukemia. She was rushed to MD Anderson in Houston, Texas, to undergo immediate remissive treatment. For the next two and a half years, my parents lived in Houston, hoping to beat cancer. They routinely came home every sixty to ninety days for a week or so. I was ten when she was diagnosed with ALL, and I was mad, mad as hell. Not at "the cancer" but everything and everyone, especially my mom. My thinking was, "how could she do this to me? to all of us?" My immaturity questioned, "Why me?" but not the reality that my mom was sick and that she needed me just as much as I needed her.

Spring Break 2017, there she was, lying lifeless in a dimly lit room, blanket wrapped from the neck-down, motionless. I can still remember the humming of the fluorescent lights in pure replication of an ECG tone; constant, steady, monotone, and without change or life. In the five or so minutes that I stood there looking over her, my heart pounding from my chest, my eyes filled with tears, and my legs heavy as if cemented in concrete; there was nothing I could say, nothing I could do to bring her back, so I just cried. My dad was bent over whispering in her ear, trying his best to keep it together, when he suddenly directed us to say our goodbyes. I didn't want to leave or say goodbye, as I was consumed with guilt, shame, and rage.

The next thing I remember is the GPS on my dad's phone callout, "You will reach your destination in seven hours and forty-seven minutes." For the next ten hours, I cried myself to sleep, hoping to wake from this nightmare. Somewhere between the onslaught of raging profanity from my dad and the aimless daze of the drive, my father pulled over. He looked us all in the eye and said, "kids, there are two paths set before you tonight, a path in which you can be a victim of your mother's tragic death or the path to which you can honor your mother and be what your mother envisioned and bequeathed upon each of you." I can not honestly say it was at that moment that I wanted to honor my mother's dreams for me, but it was at that moment that I recognized, and it still resonates inside of me, that "I am against ALL."

It took some time, but I eventually incorporated honoring my mom's dreams by diving into my education; taking my classes to the highest level, reading relentlessly, and joining numerous social clubs and community activities. After becoming a dual State qualifier in debate and mock trial as co-counsel, one might think it would be easy to talk of my mother's death and all the pain and struggles our family endures, yet it is just the opposite. Losing my mom could have resulted in a negative outcome in my life's pathway. However, I chose not to be a victim but to face struggles head-on. I am setting high standards to honor my mother's memory. Mom, I write this today to say I'm Ok, that we are ok. I started a non-profit in your honor [www.iAMagainstALL.org] to help others facing the struggles we endured. As you watch over us from above, I will continue to watch over our family, and I promise you that I will become the very best I can be.



Foundation Founders

Ami Paige Foundation

Kaden "Whit" Brown

Co-Founder and CEO

Chandler Paige Brown

Co-Founder

Beckett Winston Brown

Co-Founder

Kyle C. Brown

Dad - Advisory Board Director

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